abstract：:There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was...

journal_title：Journal of dental research

authors： Peres MA,Sheiham A,Liu P,Demarco FF,Silva AE,Assunção MC,Menezes AM,Barros FC,Peres KG

更新日期：2016-04-01 00:00:00

abstract：:Periodontitis is a chronic inflammatory disease induced by a biofilm that forms on the tooth surface. Increased periodontal disease is associated with aging. We investigated the effect of aging on challenge by oral pathogens, examining the host response, colonization, and osteoclast numbers in aged versus young mice. ...

journal_title：Journal of dental research

authors： Wu Y,Dong G,Xiao W,Xiao E,Miao F,Syverson A,Missaghian N,Vafa R,Cabrera-Ortega AA,Rossa C Jr,Graves DT

更新日期：2016-04-01 00:00:00

abstract：:The aim of this study was to examine the association between the bone mass (bone mineral content [BMC]) and hypomineralized second primary molars (HSPMs)/molar incisor hypomineralization (MIH) in 6-y-old children. This cross-sectional study was embedded in the Generation R Study, a population-based prospective cohort ...

journal_title：Journal of dental research

authors： van der Tas JT,Elfrink ME,Vucic S,Heppe DH,Veerkamp JS,Jaddoe VW,Rivadeneira F,Hofman A,Moll HA,Wolvius EB

更新日期：2016-04-01 00:00:00

abstract：:Dental caries is a microbially mediated disease that can result in significant tooth structure degradation. Although the preponderance of lesions is treated by surgical intervention, various strategies have been developed for its noninvasive management. Here, we use a novel approach for noninvasive treatment based on ...

journal_title：Journal of dental research

authors： Kerr JE,Arndt GD,Byerly DL,Rubinovitz R,Theriot CA,Stangel I

更新日期：2016-03-01 00:00:00

abstract：:The junctional epithelium (JE) is unique with regard to its wide intercellular spaces and sparsely developed intercellular junctions. Thus, knowledge of the molecular mechanisms that regulate the formation of the intercellular junctions of the junctional epithelium may be essential to understand the pathophysiology of...

journal_title：Journal of dental research

authors： Lee G,Kim HJ,Kim HM

更新日期：2016-03-01 00:00:00

abstract：:The balance between bone resorption and bone formation is vital for maintenance and regeneration of alveolar bone and supporting structures around teeth and dental implants. Tissue regeneration in the oral cavity is regulated by multiple cell types, signaling mechanisms, and matrix interactions. A goal for periodontal...

journal_title：Journal of dental research

authors： Larsson L,Decker AM,Nibali L,Pilipchuk SP,Berglundh T,Giannobile WV

更新日期：2016-03-01 00:00:00

abstract：:Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in adults and occurs in about 50% of the US population. In addition to the clinical challenges associated with treating periodontitis, the pro...

journal_title：Journal of dental research

authors： Martins MD,Jiao Y,Larsson L,Almeida LO,Garaicoa-Pazmino C,Le JM,Squarize CH,Inohara N,Giannobile WV,Castilho RM

更新日期：2016-02-01 00:00:00

abstract：:Inflammatory conditions as they occur during periodontal disease often result in decreased alveolar bone levels and a loss of connective tissue homeostasis. Here we have focused on the effect of microRNA-138 (miR-138) as a potential regulator of periodontal stem cells as they affect homeostasis during inflammatory con...

journal_title：Journal of dental research

authors： Zhou X,Luan X,Chen Z,Francis M,Gopinathan G,Li W,Lu X,Li S,Wu C,Diekwisch TG

更新日期：2016-02-01 00:00:00

abstract：:The oral microbiota was compared between Romanian adolescents with a high prevalence of caries and no dental care and Swedish caries-active and caries-free adolescents in caries prevention programs and with a low prevalence of caries. Biofilm samples were analyzed by FLX+ pyrosequencing of the V1 to V4 hypervariable r...

journal_title：Journal of dental research

authors： Johansson I,Witkowska E,Kaveh B,Lif Holgerson P,Tanner AC

更新日期：2016-01-01 00:00:00

abstract：:The etiology of dental caries reflects a complex interplay of biochemical, microbial, genetic, social and physical environmental, and health-influencing behavioral factors. This review updates the literature on the efficacy of behavioral approaches to caries prevention for children up to 18 y of age. Included were stu...

journal_title：Journal of dental research

authors： Albino J,Tiwari T

更新日期：2016-01-01 00:00:00

abstract：:Recent advances in molecular biology have facilitated analyses of the oral microbiome ("Who are they?"); however, its functions (e.g., metabolic activities) are poorly understood ("What are they doing?"). This review aims to summarize our current understanding of the metabolism of the oral microbiome. Saccharolytic ba...

journal_title：Journal of dental research

authors： Takahashi N

更新日期：2015-12-01 00:00:00

abstract：:Mesenchymal stem cells isolated from different dental tissues have been described to have osteogenic/odontogenic-like differentiation capacity, but little attention has been paid to the biochemical composition of the material that each produces. Here, we used Raman spectroscopy to analyze the mineralized materials pro...

journal_title：Journal of dental research

authors： Volponi AA,Gentleman E,Fatscher R,Pang YW,Gentleman MM,Sharpe PT

更新日期：2015-11-01 00:00:00

abstract：:Stem cells are remarkable, and stem cell-based tissue engineering is an emerging field of biomedical science aiming to restore damaged tissue or organs. In dentistry and reconstructive facial surgery, it is of great interest to restore lost teeth or craniofacial bone defects using stem cell-mediated therapy. In the cr...

journal_title：Journal of dental research

authors： Zhao H,Chai Y

更新日期：2015-11-01 00:00:00

abstract：:Saliva plays a major role in maintaining oral health. Patients with salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay, periodontal disease, and microbial infections. At this time, treatments for hyposalivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpi...

journal_title：Journal of dental research

authors： Maruyama CL,Leigh NJ,Nelson JW,McCall AD,Mellas RE,Lei P,Andreadis ST,Baker OJ

更新日期：2015-11-01 00:00:00

abstract：:A complex feedback mechanism between parathyroid hormone (PTH), 1,25(OH)2D3 (1,25D), and fibroblast growth factor 23 (FGF-23) maintains mineral homeostasis, in part by regulating calcium and phosphate absorption/reabsorption. Previously, we showed that 1,25D regulates mineral homeostasis by repressing dentin matrix pr...

journal_title：Journal of dental research

authors： Wang L,Tran AB,Nociti FH Jr,Thumbigere-Math V,Foster BL,Krieger CC,Kantovitz KR,Novince CM,Koh AJ,McCauley LK,Somerman MJ

更新日期：2015-10-01 00:00:00

abstract：:The dental pulp in human primary teeth is densely innervated by a plethora of nerve endings at the coronal pulp-dentin interface. This study analyzed how the physiological root resorption (PRR) process affects dental pulp innervation before exfoliation of primary teeth. Forty-four primary canine teeth, classified into...

journal_title：Journal of dental research

authors： Suzuki K,Lovera M,Schmachtenberg O,Couve E

更新日期：2015-10-01 00:00:00

abstract：:Reporting the economic burden of oral diseases is important to evaluate the societal relevance of preventing and addressing oral diseases. In addition to treatment costs, there are indirect costs to consider, mainly in terms of productivity losses due to absenteeism from work. The purpose of the present study was to e...

journal_title：Journal of dental research

authors： Listl S,Galloway J,Mossey PA,Marcenes W

更新日期：2015-10-01 00:00:00

abstract：:Alendronate (ALN) is an antiresorptive agent widely used for the treatment of osteoporosis. Its suppressive effect on osteoclasts has been extensively studied. However, the effect of ALN on bone formation is not as clear as its effect on resorption. The objective was to determine the effect of short-term ALN on bone f...

journal_title：Journal of dental research

authors： Tanoue R,Koi K,Yamashita J

更新日期：2015-09-01 00:00:00

abstract：:Periodontal inflammation and alveolar bone remodeling during orthodontic tooth movement are considered regional reactions. However, how systemic immune responses are involved in this regional reaction remains unclear. In this study, we explored the systemic effects of orthodontic force by focusing on the mononuclear p...

journal_title：Journal of dental research

authors： Zeng M,Kou X,Yang R,Liu D,Wang X,Song Y,Zhang J,Yan Y,Liu F,He D,Gan Y,Zhou Y

更新日期：2015-09-01 00:00:00

abstract：:When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal es...

journal_title：Journal of dental research

authors： Slade GD,Sanders AE,Ohrbach R,Bair E,Maixner W,Greenspan JD,Fillingim RB,Smith S,Diatchenko L

更新日期：2015-09-01 00:00:00

abstract：:The effect of chronic fluoride (F) exposure from the drinking water on parameters related to glucose homeostasis was investigated. Wistar rats were randomly distributed into 2 groups (diabetic [D] and nondiabetic [ND]; n = 54 each). In D, diabetes was induced with streptozotocin. Each group was further divided into 3 ...

journal_title：Journal of dental research

authors： Lobo JG,Leite AL,Pereira HA,Fernandes MS,Peres-Buzalaf C,Sumida DH,Rigalli A,Buzalaf MA

更新日期：2015-07-01 00:00:00

abstract：:A dental appointment commonly prompts fear of a painful experience, yet we have never fully understood how our brains react to the expectation of imminent tooth pain once in a dental chair. In our study, 21 patients with hypersensitive teeth were tested using nonpainful and painful stimuli in a clinical setting. Subje...

journal_title：Journal of dental research

authors： Racek AJ,Hu X,Nascimento TD,Bender MC,Khatib L,Chiego D Jr,Holland GR,Bauer P,McDonald N,Ellwood RP,DaSilva AF

更新日期：2015-07-01 00:00:00

abstract：:It was recently reported that human periapical cysts (hPCys), a commonly occurring odontogenic cystic lesion of inflammatory origin, contain mesenchymal stem cells (MSCs) with the capacity for self-renewal and multilineage differentiation. In this study, periapical inflammatory cysts were compared with dental pulp to ...

journal_title：Journal of dental research

authors： Marrelli M,Paduano F,Tatullo M

更新日期：2015-06-01 00:00:00

abstract：:Lactoferrin is one of a number of multifunctional proteins that are present in or on all mucosal surfaces throughout the body. Levels of lactoferrin are consistently elevated in inflammatory diseases such as arthritis, inflammatory bowel diseases, corneal disease, and periodontitis. Single-nucleotide polymorphisms (SN...

journal_title：Journal of dental research

authors： Fine DH

更新日期：2015-06-01 00:00:00

abstract：:This study investigated the relevance between pulp vitality and autophagy in aged human dental pulp cells (HDPCs) and whether peroxisome proliferator-activated receptor gamma (PPARγ) affects autophagy regulation for homeostasis in the aging progress. In vivo experiments were used in human and Sprague-Dawley rat teeth ...

journal_title：Journal of dental research

authors： Lee YH,Lee HY,Kim TG,Lee NH,Yu MK,Yi HK

更新日期：2015-05-01 00:00:00

abstract：:Mutations in ALPL result in hypophosphatasia (HPP), a disease causing defective skeletal mineralization. ALPL encodes tissue nonspecific alkaline phosphatase (ALP), an enzyme that promotes mineralization by reducing inorganic pyrophosphate, a mineralization inhibitor. In addition to skeletal defects, HPP causes dental...

journal_title：Journal of dental research

authors： Foster BL,Sheen CR,Hatch NE,Liu J,Cory E,Narisawa S,Kiffer-Moreira T,Sah RL,Whyte MP,Somerman MJ,Millán JL

更新日期：2015-05-01 00:00:00

abstract：:Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malocclusion. MP is a complex genetic trait, although familial recurrence also suggests the contribution of single inherited variations. To date, the genetic causes of MP have been investigated using linkage analysis or ass...

journal_title：Journal of dental research

authors： Perillo L,Monsurrò A,Bonci E,Torella A,Mutarelli M,Nigro V

更新日期：2015-04-01 00:00:00

abstract：:Medication-related osteonecrosis of the jaw (MRONJ), although initially believed to be exclusively associated with bisphosphonates, has been implicated in recent reports with additional drugs, especially the bone antiresorptive denosumab. The pathophysiology has not been fully elucidated, and no causal association bet...

journal_title：Journal of dental research

authors： Katsarelis H,Shah NP,Dhariwal DK,Pazianas M

更新日期：2015-04-01 00:00:00

abstract：:Cleidocranial dysplasia (CCD) is a skeletal dysplasia caused by heterozygous mutations of RUNX2, a gene that is essential for the mineralization of bone and tooth. We isolated primary dental pulp cells from a 10-y-old patient and tested their proliferative capacity, alkaline phosphatase activity, and ability to form m...

journal_title：Journal of dental research

authors： Yan WJ,Zhang CY,Yang X,Liu ZN,Wang XZ,Sun XY,Wang YX,Zheng SG

更新日期：2015-04-01 00:00:00

abstract：:Bone and dentin share similar biochemical compositions and physiological properties. Dentin, a major tooth component, is formed by odontoblasts; in contrast, bone is produced by osteoblasts. Osterix (Osx), a zinc finger-containing transcription factor, has been identified as an essential regulator of osteoblast differ...

journal_title：Journal of dental research

authors： Kim TH,Bae CH,Lee JC,Kim JE,Yang X,de Crombrugghe B,Cho ES

更新日期：2015-03-01 00:00:00

abstract：:Thermal and mechanical hypersensitivity in the injured region is a common complication. Although it is well known clinically that thermal and mechanical sensitivity of the oral mucosa is different from that of the skin, the mechanisms underlying injured pain of the oral mucosa remain poorly understood. The transient r...

journal_title：Journal of dental research

authors： Urata K,Shinoda M,Honda K,Lee J,Maruno M,Ito R,Gionhaku N,Iwata K

更新日期：2015-03-01 00:00:00

abstract：:To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-...

journal_title：Journal of dental research

authors： Kühnisch J,Thiering E,Kratzsch J,Heinrich-Weltzien R,Hickel R,Heinrich J,GINIplus study group.,LISAplus study group.

更新日期：2015-02-01 00:00:00

abstract：:Clinical studies have shown that metabolic syndrome (MetS) is associated with increased risk of developing periodontitis. However, the underlying mechanisms remain largely unknown. Since it is known that lipopolysaccharide (LPS)-activated toll-like receptor 4 signaling pathways play a crucial role in periodontitis, we...

journal_title：Journal of dental research

authors： Li Y,Lu Z,Zhang X,Yu H,Kirkwood KL,Lopes-Virella MF,Huang Y

更新日期：2015-02-01 00:00:00

abstract：:The objectives of this study were 1) to provide an estimate of the value of the intraclass correlation coefficient (ICC) for dental caries data at tooth and surface level, 2) to provide an estimate of the design effect (DE) to be used in the determination of sample size estimates for future dental surveys, and 3) to e...

journal_title：Journal of dental research

authors： Masood M,Masood Y,Newton JT

更新日期：2015-02-01 00:00:00

abstract：:Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated os...

journal_title：Journal of dental research

authors： Liu Y,Chen C,Liu S,Liu D,Xu X,Chen X,Shi S

更新日期：2015-01-01 00:00:00

abstract：:In this study, we first investigated the expressions of Jagged1, Notch2, the receptor activator of nuclear factor-kappa B ligand (RANKL), and interleukin (IL)-6 in areas of root resorption during experimental tooth movement in rats in vivo. We then assessed the effects of compression force (CF) with or without GSI (an...

journal_title：Journal of dental research

authors： Kikuta J,Yamaguchi M,Shimizu M,Yoshino T,Kasai K

更新日期：2015-01-01 00:00:00

abstract：:The dentition in zebrafish is extremely and richly vascularized, but the function of the vasculature, in view of the continuous replacement of the teeth, remains elusive. Through application of SU5416, a vascular endothelial growth factor receptor inhibitor, we studied the role of the blood vessels in the dentition of...

journal_title：Journal of dental research

authors： Crucke J,Huysseune A

更新日期：2015-01-01 00:00:00

abstract：:Large mandibular defects are difficult to reconstruct with good functional and aesthetic outcomes because of the complex geometry of craniofacial bone. While the current gold standard is free tissue flap transfer, this treatment is limited in fidelity by the shape of the harvested tissue and can result in significant ...

journal_title：Journal of dental research

authors： Tatara AM,Wong ME,Mikos AG

更新日期：2014-12-01 00:00:00

abstract：:This study aims at modifying dual-cure composite cements by adding thio-urethane oligomers to improve mechanical properties, especially fracture toughness, and reduce polymerization stress. Thiol-functionalized oligomers were synthesized by combining 1,3-bis(1-isocyanato-1-methylethyl)benzene with trimethylol-tris-3-m...

journal_title：Journal of dental research

authors： Bacchi A,Dobson A,Ferracane JL,Consani R,Pfeifer CS

更新日期：2014-12-01 00:00:00

abstract：:Minimal invasive approaches to managing caries, such as partial caries removal techniques, are showing increasing evidence of improved outcomes over the conventional complete caries removal. There is also increasing interest in techniques where no caries is removed. We present the 1-yr results of clinical efficacy for...

journal_title：Journal of dental research

authors： Santamaria RM,Innes NP,Machiulskiene V,Evans DJ,Splieth CH

更新日期：2014-11-01 00:00:00